Taxim-O 200mg (cefixime)

Cefixime(Taxim-O) is an 3rd generation oral cephalosporin antibiotic. It is administered to take care of tonsilitis, gonorrhea, as well as pharyngitis. The normal dosage is 400 mg in 2 separate doses for a period of about one week.

Pharmacodynamics

Pharmacokinetics

Cefixime holds on to one or more of the PBPs (penicillin-binding proteins) which reduces the last transpeptidation process of peptidoglycan production in bacterial cell wall, as a result restraining biosynthesis and checking cell wall congregation ensuing death of bacterial cell.

Absorption

Only 40 to 50 percent is absorbed from the Gastro Intestinal tract (oral); absorption rate might be reduced if administered with food. Better absorption observed with oral suspension than Taxim-O 200mg (cefixime) tablets.

Distribution

Protein-binding: merely about 65 percent. Urine (elevated absorptions), Bile; crosses the placenta.

Excretion

20 percent of an oral dose is discharged through urine unaltered; 60 percent non renal excretion; some is eliminated through the faeces from the bile. Significantly discharged by dialysis.

Taxim-O Side Effects

Cefixime Adverse Reactions

Diarrhea, vomiting, nausea, stomach cramps, abdominal pain; dizziness, headache,eosinophilia thrombocytopenia.

Potentially lethal: Pseudomembranous colitis.

These may not be the complete list of cefixime side effects, consult a doctor for further information.

Precautions

Monitor

Observe PT in addition to subject’s reaction to treatment.

Adverse reactions

Observe subject for CNS, Gastro Intestinal, common body side effects, and symptoms of super infection.

Special Precautions

Past records of hypersensitivity to penicillin; pregnancy and lactation; renal disorders; Gastro Intestinal problems.

Other Drug Interactions

Amplified absorptions when used with probenecid.

Potentially lethal: might augment prothrombin time when used with anticoagulants.

Additional Interactions

Concentration deferred when used with food.

List of Contraindications

Cefixime and Pregnancy

To be administered with caution during pregnancy. Discuss with your doctor the possible benefits and risk to the fetus.

Cefixime and Lactation

It is not known whether cefixime is excreted in breast milk or whether it has a hazardous effect on the breastfeeding baby. Hence should be used with caution during lactation.

Efficiency and safety not recognized in kids younger than six months of age.

Cefixime and Other Contraindications

Allergic reaction to cephalosporin.

Storage

Oral

to be stored in room temperature below 25 degree Celsius.