Gynera Contraceptive Pills
Gynera contraceptive pills
Active ingredients- Ethinylestradiol and gestodene.
Mechanism of action
Pharmacology: The contraceptive action of Gynera is supported on the effects of a range of aspects, the most significant of which are observed as the prevention of ovulation and the alterations in the cervical discharge.
Gestodene: When used orally, gestodene is quickly and fully absorbed. Following particular intake of Gynera, highest drug serum levels are attained roughly in an hour. Subsequently, the level of gestodene serum reduces in 2 stages. The last disposition stage is differentiated by a half-life of 12 to 15 hours. Gestodene is attached to serum albumin and to sex hormone-binding globulin (SHBG). Merely 1 to 2 percent of the entire serum medicine levels are there as liberated steroid, nearly 50 to 70 percent are explicitly attached to sex hormone-binding globulin.
Following every day continual use of Gynera, gestodene absorptions in the serum amplify by a factor of about 2.8. Average serum levels are four times higher at normal situations which are attained during the 2nd phase of the therapy period. The pharmacokinetics of gestodene is affected by levels of SHBG serum. Under management with Gynera, a three times enhancement in the levels of serum SHBG has been reported for the 1st phase of the therapy period.
Owing to the precise binding of gestodene to sex hormone-binding globulin (SHBG), the boost in SHBG levels is escorted by an approximately equivalent boost in levels of gestodene serum. Following the third therapy phase the degree of SHBG stimulation per phase does not alter any further. The complete bioavailability of gestodene was established to be 99 percent of the amount used.
Ethinylestradiol: Orally used ethinylestradiol is quickly and fully absorbed. Following intake of Gynera, highest levels of drug serum are attained at roughly 1.4 hours. Subsequently, levels of ethinylestradiol serum reduce in two stages differentiated by half-lives of 1 to 2 hours and about 20 hours. Ethinylestradiol is extremely but not distinctively attached to serum albumin. About 2 percent of drug levels are there unattached.
A per the half-life of the final disposition stage from serum and the everyday intake, normal state serum levels are attained after roughly 3 to 4 days and are higher by 30 to 40 percent as evaluated to a particular quantity.