Virlix (Cetirizine diHCl)
Mechanism of action
Pharmacology: Cetirizine, is a powerful and discretionary antagonist of secondary H1-receptors.
Along with its anti-H1 action, cetirizine was exposed to exhibit anti-allergic actions at a dosage of 10 mg one time or twice every day. It checks the delayed stage conscription of seditious cells, particularly eosinophils, in the conjunctiva and skin of atopic subjects presented to antigen challenge and the amount of 30 mg per day stops the incursion of eosinophils in the broncho alveolar lavage fluid at some stage in a late stage bronchial restriction stimulated by allergen breathing in asthmatic patients. Furthermore, cetirizine stops the delayed phase seditious effect stimulated in chronic urticaria subjects by intra-dermal use of kallikrein.
Virlix Indications/ uses
Adults, kids, child and Toddlers greater than a year: Relief of nasal signss of cyclic and chronic allergic rhinitis for example- nasal pruritus, rhinorrhea and sneezing, along with non-nasal signs connected with conjunctivitis.
It also is used for treating different kinds of pruritus as well as urticaria which include chronic idiopathic urticaria.
- Past accounts of allergic reaction to any of the active ingredients of Virlix, hydroxyzine or to a few piperazine extracts.
- Patients with acute renal problems.
- Rare genetic disorders of the Lapp-lactase deficiency, galactose intolerance, or glucose-galactose mal-absorption;
- Rare genetic disorders of fructose intolerance must avoid using Virlix 1 mg/mL oral solution.
Virlix side effects
Medical experiments have revealed that cetirizine at the suggested quantity has negligible side effects on the CNS which include fatigue, somnolence, dizziness along with headache. In a number of situations, inconsistent CNS stimulation has been observed.
Propyl parahydroxybenzoate and Methyl parahydroxybenzoate formulated in Virlix 10 mg per mL oral drops and in Virlix 1 mg per mL oral solution might stimulate hyper sensitivity (probably deferred).
Even though cetirizine is a selective antagonist of peripheral H1-receptors and is moderately liberated of anti-cholinergic action, inaccessible cases of micturition problems, eye accommodation problems and dry mouth have been observed.
Cases of uncharacteristic hepatic problems with prominent hepatic enzymes attended by eminent bilirubin have been observed. More often than not this go away upon stopping the adminstration of the drug.