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Vasograin (Ergotamine) for Treating Migraine

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Vasograin (Ergotamine) for treating migraine Vasograin (Ergotamine) is an ergo-peptine and component of the ergot group of alkaloids; it is biochemically and structurally strongly associated to ergoline. It enjoys structural relationship to a number of

Vasograin (Ergotamine) for treating migraine

Vasograin (Ergotamine) is an ergo-peptine and component of the ergot group of alkaloids; it is biochemically and structurally strongly associated to ergoline. It enjoys structural relationship to a number of neuro-transmitters, and has organic action as a vaso constrictor. Vasograin (Ergotamine) is administered clinically for treating acute migraine attacks (occasionally together with caffeine), and to stimulate child birth and avoid postpartum hemorrhage.

Pharmacodynamics

Pharmacokinetics

Ergotamine has distinct vasoconstrictor actions and biased agonistic properties at serotonin receptors. Vasograin imbibes restriction of cranial and secondary blood vessels and also has influential oxytocic effect on the uterus. It also decreases hyper perfusion in the basilar artery areas.

Absorption

Vasograin (Ergotamine) is inadequately concentrated from the GI tract (oral, sublingual), reduced additionally by gastric stasis.

Distribution

Penetrates via breast milk

Metabolism

widespread hepatic initial pass action.

Excretion

Vasograin is discharged through bile, urine (4%); eradication T 1/2 (biphasic): 2 hour (preliminary stage), 21 hour (final stage).

Ergotamine Adverse Reactions

Vasograin Side Effects

Stiffness, muscle cramps, tiredness, lack of sensation and itchy edges, vomiting, Nausea, diarrhea. anginal pain, Ergotism comprising of hypo tension and gangrene of edges, and momentary bradycardia or tachycardia. These are not the complete list of Vasograin Side Effects, for detailed information consult a doctor.

Potentially Fatal: CV disturbances and acute secondary vasoconstriction. As a result of vascular occlusions resulting in bowel necrosis, MI, gangrene and renal failure. Concurrent use of oral contraceptives or beta-blockers amplifies the danger.

Special Precautions

• Patients suffering from Anemia;

• Observe for symptoms of ergotism such as lack of feeling or itchy edges.

Other Drug Interactions

Vasoconstrictor actions improved by sympathomimetic properties e.g. adrenaline. Caffeine boos the effect of ergotamine.

Potentially Fatal: Use within six hour of taking serotonin agonist may cause amplified and protracted vaso pastic actions. May also have augmented danger of secondary vasoconstriction with beta blockers. Erythromycin augments plasma concentration of ergotamine which result in ergotism.

Food(before/after)

Vasograin may be used before or after food for treating migraine.

Ergotamine and Other Contraindications

Acute or hysterical hypertension, lactation, pregnancy, secondary vascular ailments, infected conditions hyperthyroidism, , ischaemic heart disease, injured hepatic or renal failure, allergic reaction, collagen disease cachexia, and fibrotic conditions.

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Niitesh Mundra

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