Side Effects of Predmet (methylprednisolone) Tablets
Side effects of Predmet (methylprednisolone) tablets
The most commonly reported adverse effects with Predmet (methylprednisolone) tablets are:
Fluid and electrolyte disturbances: Sodium retention, congestive heart failure in susceptible patients, hypertension, fluid retention, potassium loss, hypokalemic alkalosis.
Musculoskeletal Side effects of Predmet (methylprednisolone) tablets
Muscle weakness, loss of muscle mass, steroid myopathy, osteoporosis, tendon rupture particularly of the Achilles tendon, vertebral compression fractures, aseptic necrosis of femoral and humeral heads, pathologic fractures of long bones. Gastrointestinal: Dyspepsia, peptic ulceration with possible perforation and hemorrhage, pancreatitis, abdominal distention, ulcerative esophagitis, esophageal candidiasis, perforation of bowel. Increases in alanine transaminase (ALT, SGPT), aspartate transaminase (AST, SGOT), alkaline phosphatase have been observed following corticosteroid treatment. These transformations are usually small, not related with any clinical syndrome and are retractable upon discontinuation.
Dermatologic Side effects of Predmet (methylprednisolone) tablets
Impaired wound healing, skin atrophy, bruising', telangiectasia, striae, acne, petechiae, ecchymoses, suppress reactions to skin tests, thin fragile skin, facial erythema, increased sweating.
Neuropsychiatric: Increased intracranial pressure with papilledema (pseudo-tumor cerebri); convulsions, vertigo, headache, euphoria, psychological dependence, mood swings, depression, personality changes, insomnia, psychosis, aggravation of schizophrenia, seizures.
Endocrine Side effects of Predmet (methylprednisolone) tablets
Development of Cushingoid state, hirsutism, weight gain, increased appetite, suppression of growth in children, secondary adrenocortical and pituitary insensitivity (particularly in period of trauma, as in stress, surgery or illness), menstrual irregularities, amenorrhoea, decreased carbohydrate tolerance, manifestations of latent diabetes mellitus, increased requirements of insulin or oral hypoglycemic agents in diabetics. Ophthalmic: Posterior subcapsular cataracts, increased intraocular pressure, glaucoma, corneal or scleral thinning, exacerbation of ophthalmic viral orfungal disease, exophthalmos. Metabolic: Negative nitrogen equilibrium due to protein catabolism. Immune system: Masking of infections, latent-infections becoming active, opportunistic infections, recurrence of dormant tuberculosis,
General: Urticaria, leucocytosis, thromboembolism, nausea, malaise, and other allergic, anaphylactic or hypersensitivity reactions.
Withdrawal symptoms after taking Predmet (methylprednisolone) tablets
Too rapid a reduction of the corticosteroid dose following prolonged treatment can lead to acute adrenal insufficiency, hypotension and death. A withdrawal syndrome may also take place including fever, myalgia, arthralgia, rhinitis, painful itchy skin nodules, conjunctivitis and loss of weight. Administration of methylprednisolone should not be discontinued abruptly but tailed off over a period of time. Suitable action should be taken to ease the symptoms created by any side effect that may become obvious.