Secnidazole 500mgFitness Gear & Equipment
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Secnidazole is a synthetic derivative of the series of nitroimidazoles. Its antiparasitic activity affects: Entamoeba histolytica, Giardia lamblia, Trichomonas vaginalis and Gardnerella vaginalis.
The secnidazole is a synthetic derivative of 5-nitroimidazoles long half-life (within which is also metronidazole and tinidazole)
The secnidazole is slowly and completely absorbed after oral administration, the maximum concentration peak is obtained at the third hour, the plasma half-life is around 25 hours, joined by 15% to plasma proteins and has a well distributed throughout the body, including crosses the placental barrier and is excreted in breast milk .
Your metabolism is probably in the liver resulting from hydroxyl acids. Elimination is essentially urinary and slow so that patients with amebiasis and giardiasis are a healing response with 2 g (30 mg / kg in children) in a single day.
Its elimination half-life in blood is 28.8 hours and 30.4 hours in plasma .
The secnidazole has activity against anaerobic microorganisms, particularly against the germs that cause amebiasis, trichomoniasis, giardiasis and vaginal trichomoniasis.
After administration of a dose of secnidazole you get a parasite eradication of approximately 92 to 100% .
Secnidazole action is determined in vitro by DNA degradation and inhibition of nucleic acid synthesis, effective during mitosis or not.
Due to its slow absorption may stay longer in the intestinal lumen and does its ground action against intestinal parasites such as giardia and amoeba .
Intestinal or hepatic amebiasis
Nephritis and vaginitis caused by Trichomonas vaginalis
Eradication of Helicobacter pylori in combination with inhibitors of proton pump as omeprazole
No evidence of teratogenicity in humans but no reliable studies have been conducted to eliminate this possibility, so it must not be operated in the first trimester of pregnancy, in the second and third is the responsibility of the physician to evaluate the risk-benefit ratio. Not be administered to nursing women.
It should be administered to patients who report secnidazole hypersensitivity to imidazole derivatives, blood dyscrasias, CNS diseases and children under 2 years. Do not drink alcohol during treatment.