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Propranolol Tablet - A Perfect Beta Blocker

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Propanolol is probably the most popular beta blocker which is ruling for the last 50 years .It is highly lipid soluble and thus enters the brain barrier and exerts actions on some 5HT Receptors .Propranolol not only reduces the blood pressure but also red

Propranolol is probably the most popular beta blocker which is ruling for the last 50 years .It is highly lipid soluble and thus enters the brain barrier and exerts actions on some 5HT Receptors .Propranolol not only reduces the blood pressure but also reduce the workload of the myocardial. For the membrane stabilizing action –it’s given frequently in case of cardiac arrhythmias. This white crystalline product having a competition with the other beta adrenergic agonist receptors to exerts the actions and probably proved the best also.

Dosage Forms – Mainly given in 10 to 40 mg doses with twice or thrice or as directed by the Physician in case of hypertension but yes in Myocardial infarction the dose been increased up to 4-5 times in separate doses. In case of Pheochromocytoma,it is given with an alpha blocker daily in total of 60mg daily dose but yes in divided doses. In Arial fibrillation, low doses of 10 to 30 mg been given in a total of 3-4 doses daily in divided dose.

Uses – Propranolol is appropriate to use in angina pectoris as its having the ability to reduce the frequency of this disease state. Its having the ability to reduce the blood pressure, thus decreases the chance of heart disease occurrence .Its also reduces the chances of the second acute myocardial attack. In absence of Timolol, it could be given in case of Glaucoma if needed. It also controls the ventricular rate in patients with atrial fibrillation. Migraine attack treatment been done with this sometimes .Even essential tremors are being treated by this Propranolol.

Drug Interaction

Not recommended for the patients receiving insulin as it may cause adverse effects on the Glucose and Lipid metabolism.

Barbiturates if given with Propanolol may reduce its effect .Precipitation of Heart attack occurs if it is used with Verapamil .

Safety Alerts – Safety Alerts been given to the patients who are suffering from Bronchial asthma, Severe Hemorrhage and Cardiac shock.

Adverse Drug Reaction – There is a chance of severe bradycardia development .Patients, who is suffering from myocardial disease – sudden withdrawal of Propranolol is not suggested to them. There are also cases of Hypotension also. Sudden withdrawal may sometime causes Hyperthyroidism. Nausea and constipation may occur. Impotence cases also been reported in many instances. Mood alteration, dizziness been seen.

Food interaction – Sometimes there are chances of absorption delay and the amount of drug in the blood circulation also increases but yes the sustain pattern remains the same.

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