Predmet (methylprednisolone) Tablets
Methylprednisolone Tablets IP
Each uncoated tablet of Predmet contains Methylprednisolone IP 4 mg, 8 mg, 16 mg or 24 mg.
Predmet (methylprednisolone) tablets is available as (tablets in blisters of 10)
• Predmet 4 mg
• Predmet 8 mg
• Predmet 16 mg
• Predmet 24 mg
Predmet (Methylprednisoione)is a synthetic glucocorticoid.
How Predmet (Methylprednisoione) Works
Glucocorticoids diffuse across cell membranes and complex with specific cytoplasmic receptors. These complexes then enter the cell nucleus, bind to ONA (chromatin) and stimulate transcription of mRNA and subsequent protein synthesis of various enzymes thought to be ultimately responsible for the effects of systemic use of glucocorticoids. Glucocorticoids not only have an important influence on inflammatory and immune processes, but also affect the carbohydrate, protein and fat metabolism. They also take steps on the cardiovascular system, the skeletal muscles and the inner nervous system. The anti-inflammatory, immunosuppressive and antiallergic, properties of glucocorticoids are responsible for most of the therapeutic applications. These properties lead to reduction of the immunoactive cells near the inflammation focus; condensed vasodilation; calming down of the lysosomal membranes; reticence of phagocytosis; decreased making of prostaglandins and related substances. Glucocorticoids have protein catabolic and lipolytic actions.
Pharmacokinetics of Predmet (methylprednisolone) tablets
In vivo perfusion in the human small intestine indicated steroids are absorbed chiefly in the proximal portion of the small intestine Absorption in the distal portion was about 50% the proximal rate. In man methylprednisolone forms a feeble dissociable attachment with albumin and transcortin. Approximately 40 to 90% of the drug is bound. Metabolism of Prdemet (methylprednisolone) happens via hepatic routes qualitatively analogous to that of Cortisol. The major metabolites are 20-beta-hydroxymethylprednisolone and 20-beta-hydroxy-6-alpha-methySprednisolone. The metabolites are excreted in the urine as glucuronides sulfates and unconjugated compounds. These conjugation reactions occur predominantly in the liver and to some level in the kidney.
Overdosage of Predmet (methylprednisolone) tablets
There is no clinical syndrome of acute overdosage with Predmet (methylprednisolone) tablets. Predmet (methylprednisolone) is dialysable. Repeated frequent doses of Predmet (daily or several times per week) over a protracted period may result in a Cushingoid state and other complications with chronic steroid therapy. It may be obligatory to sustain the patient with corticosteroids at some point in any added period of trauma happening within two years of overdosage.