Lactocal (Calcium Carbonate + Vitamin D3)

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Lactocal (Calcium Carbonate + Vitamin D3) Pharmacokinetics Calcium carbonate belongs to the group of calcium enhancement that is administered in deficiency conditions and as an appendage in the impediment and management of osteoporosis. Vitamin

Lactocal (Calcium Carbonate + Vitamin D3)

 

Pharmacokinetics

Calcium carbonate belongs to the group of calcium enhancement that is administered in deficiency conditions and as an appendage in the impediment and management of osteoporosis. Vitamin D3 belongs to the group of fat-soluble sterol and aids in the controlling of calcium and phosphate homeostasis in addition to bone mineralization.

Absorption

Calcium carbonate: Approximately 15 to 25 percent gets metabolized in the gastrointestinal tract which is changed to calcium chloride due to the presence of gastric acid.

Vitamin D: Properly absorbed in the gastrointestinal tract due to the presence of bile.

Metabolism

Vitamin D: Goes through hydroxylation in the liver as well as kidney to change to the dynamic metabolite, 1,25-dihydrocolecalciferol.

Excretion

Vitamin D and along with additional metabolites are chiefly discharged via bile and feces.

Lactocal Side Effects

May cause constipation, nausea, abdominal pain, flatulence and diarrhea. Pruritus, urticaria and rash. Consult your physician in case the problem becomes persistent and bothersome

Special Precautions

Weakened calcium concentration in achlorhydria which is widespread in aged patient. Amplified danger of hypercalciuria  and hypercalcaemia in hypoparathyroid subjects using increased amount of vitamin D. Vigilance when administering in subjects with past records of kidney stones. Renal disorders; regular observation of phosphorus along with serum calcium is advised.

Other Drug Interactions

Might influence the metabolism of tetracycline when administered concurrently. Concomitant adminstration with general corticosteroids may decrease calcium assimilation. Thiazide diuretics can reduce urinary discharge of calcium. Concomitant adminstration with ion-exchange resins can decrease Gastrointestinal assimilation of vitamin D. Hypercalcaemia can amplify the lethality of cardiac glycosides for the duration of management with Lactocal, observe serum calcium levels and ECG. Sodium fluoride or bisphosphonate ought to be administered at least three hrs prior calcium-containing solutions.

Other Interactions

Food Interaction

Foods that are loaded in oxalic acid (such as- rhubarb and spinach ) and phytic acid (such as- whole cereals) possibly will decrease calcium assimilation by development of impenetrable calcium salts, as a result calcium supplements must not be administered inside 2 hours of administering such food items.

Lactocal  and Other Contraindications

Subjects with hypercalciuria and/ or hypercalcaemia. Nephrolithiasis, hypophosphataemia, hypervitaminosis D.

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