Grilinctus BM TABLETS AND SYRUP
In various disorders such as acute and chronic bronchitis and other bronchospastic disorders such as eosinophilia, there is a spasm of the bronchial muscles and irritation of the bronchial mucous membrane, leading to breathlessness and cough. In the symptomatic management of these disorders, the mainstay of treatment consists of bronchodilators and mucolytic agents. Bronchodilators by spasmolytic action relieve broncho-constriction, thus relieving patients from troublesome breathlessness, while the mucolytic agent facilitates expulsion of accumulated sputum by reducing its viscosity and stickiness.
Terbutaline is a β2 selective bronchodilator drug. It is devoid of any significant side effects on the cardiovascular system when taken in correct dosage. Terbutaline is variably absorbed from the gastrointestinal tract and is subject to fairly extensive first-pass metabolism in the liver. It is excreted in the urine partly as metabolites and partly as unchanged Terbutaline. Bromhexine is a mucolytic mediator. It renders the sputum less viscous and less sticky and thereby facilitates its easy expulsion from the respiratory tract. Bromhexine is rapidly absorbed from the gastrointestinal tract and about 85% to 90% of a dose is excreted in the urine mainly as metabolites. Bromhexine produces a rarefaction and fragmentation of mucopolysaccharide fibres in the sputum. By this action, it reduces the viscosity of the sputum and hence is considered the drug of choice in conditions associated with productive cough.
FORMULA:Each 5 ml contains :
• Terbutaline Sulphate I.P. 2.5 mg
• Bromhexine Hydrochloride l.P. 8.0 mg
• Flavoured Syrupy base.
• Colour : Sunset Yellow FCF (Colour Index 15985)
• FORMULA ;Each uncoated tablet contains :
• Terbutaline Sulphate I.P. 2.5 mg
• Bromhexine Hydrochloride I,P. 8.0 mg
• In the symptomatic treatment of cough in acute and chronic bronchitis and other bronchospastic disorders such as eosinophilia and in smoker's cough.
SIDE EFFECTS of Grillinctus- BM
The side effects of Grillinctus- BM Syrup and Grillinctus-BM Tablets are due to the ingredients in it. Terbutaline is a β2 selective sympathomimetic agent. Hence it has side effects similar to those of sympathomimetic agents e.g. CNS side effects like anxiety, fear, tremor, restlessness, confusion.
There may be reduction of appetite and nausea and vomiting may occur. Very rarely pulmonary oedema may occur. Since Terbutaline is a β2 selective bronchodilator it is devoid of side effects related to the cardiovascular system. Gastrointestinal side effects may occur occasionally with Bromhexine and a transient rise in the serum aminotransferasevalues has been reported.
PRECAUTIONS before using Grillinctus-BM
Should be used with caution in patients with hyperthyroidism.
DRUG INTERACTIONS of Grillinctus-BM
Theophylline when given with Terbutaline can enhance the response to Terbutaline. It can also lead to a fall in the serum potassium level.
Terbutaline can reduce the serum theophylline concentrations by increasing its systemic clearance.
DOSAGE of Grillinctus-BM
Grilinctus - BM TABLETS
As directed by the Physician.
Grilinctus - BM SYRUP
Adults : One teaspoonful (5 ml) of Grilinctus - BM SYRUP three times a day or as advised by the Physician.
Grilinctus - BM Syrup is presented in a 100 ml bottle.
Grilinctus – BM Tablets are available in a blister pack of 10 tablets,
10 such blister packs in a carton.