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Fluconazole Side Effects

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Fluconazole side effects Fluconazole composition Each capsule contains fluconazole 150 mg.Excipiente (microcrystalline cellulose, sodium lauryl sulfate, magnesium stearate, starch, colloidal silicon dioxide) qs 1 capsule.

Fluconazole side effects

Fluconazole composition

Each capsule contains fluconazole 150 mg.Excipiente (microcrystalline cellulose, sodium lauryl sulfate, magnesium stearate, starch, colloidal silicon dioxide) qs 1 capsule.

Fluconazole dosage

for dermatomycoses (tinea, foot and crural) and Candida infections, fluconazole should be administered as single oral dose of 150 mg weekly. Treatment duration is usually 2 to 4 weeks, but in cases of tinea \ i pedis treatment for 6 weeks may be required. For vaginal candidiasis, fluconazole should be administered as single oral dose of 150 mg. Elderly: In cases where there is no evidence of renal impairment, doses should be used as normal. For patients with renal insufficiency (creatinine clearance <50 ml / min) should be adjusted as described below. Patients with renal impairment: Fluconazole chiefly discharged unchanged in the urine. No adjustments are required in therapy with a single dose or weekly dosing of this drug.

Overdosage: When overdosage occurs, symptomatic treatment may be adopted, including, if necessary, supportive measures and gastric lavage. Fluconazole is largely excreted in the urine, forced diuresis is expected to increase the rate of elimination. A hemodialysis session three hours decreases plasma levels by approximately 50%.

Precautions - Fluconazole

use during pregnancy: Fluconazole has been little used during pregnancy in humans. Use during pregnancy should be avoided except in patients with severe fungal infections or potentially life-threatening and where the potential benefits may outweigh the possible risks to the fetus.

Use during lactation: Fluconazole is present in breast milk in concentrations comparable to those in plasma, and thus its use in lactating women is not recommended. Use in children: the available data on the use of fluconazole in patients aged below 16 years are limited, so far, its use is not recommended in these patients unless the antifungal treatment is mandatory and there is no agents’ available suitable alternative. There are no available data on the use of fluconazole in neonates and, thus, its use in children under 1 year is not recommended.

General: Experience has shown that it is unlikely to compromise the ability to drive or handle machines with the use of fluconazole. - Interactions: It is recommended careful monitoring of prothrombin time in patients receiving coumarin anticoagulants. Fluconazole shown to prolong the plasma half-life of oral sulfonylureas (chlorpropamide, glibenclamide, glipizide and tolbutamide) when coadministered in healthy volunteers the same.

Fluconazole and oral sulphonylureas may be co-administered to diabetic patients, but the possibility of hypoglycemia should be considered. In a pharmacokinetic interaction study, coadministration of multiple doses of hydrochlorothiazide in healthy volunteers who were receiving fluconazole increased the plasma concentrations of the latter drug in 40%. This change should not require changing the dosing regimen of fluconazole in patients who are also receiving diuretics, but prescribers should keep in mind these considerations. Concomitant administration of fluconazole and phenytoin may increase the levels of the latter drug to a clinically significant degree. If necessary, administer both drugs concomitantly, phenytoin levels should be monitored and the dose adjusted to maintain therapeutic levels. It is unlikely that the use of multiple doses of fluconazole may have an effect on the efficacy of combined oral contraceptive. Interaction studies have shown that when oral fluconazole is administered concomitantly with food, cimetidine or antacids does not occur clinically significant change in the absorption of this agent. In patients receiving concomitant therapy with rifampicin, a higher dose of fluconazole should be considered. It is recommended, a concentration monitoring of cyclosporine in patients receiving fluconazole.

Fluconazole side effects

Fluconazole is generally well tolerated. The most common side effects associated with fluconazole have been those related to the gastrointestinal tract. They include nausea, abdominal pain, diarrhea and flatulence. After gastrointestinal symptoms, the second most commonly observed side effect has been rash. Headache has been associated with the use of fluconazole. In rare cases, as with other azoles, anaphylaxis has been reported with the use of fluconazole.

Contraindications - Fluconazole

is contraindicated in patients with known sensitivity to the drug or related azole compounds.

Indications - Fluconazole

treatment of acute or recurrent vaginal candidiasis.

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Niitesh Mundra

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