Enalapril and Amlodipine Combinations

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Enalapril and Amlodipine combinations Pharmacokinetics Amlodipine is from the family of 1, 4-dihydropyridine-extract calcium-channel inhibitor. Enalapril is a pro-medicine; and on oral use, it is bio-activation of hydrolysis of the ethyl ester

Enalapril and Amlodipine combinations

 

Pharmacokinetics

Amlodipine is from the family of 1, 4-dihydropyridine-extract calcium-channel inhibitor. Enalapril is a pro-medicine; and on oral use, it is bio-activation of hydrolysis of the ethyl ester which is changed to enalaprilat, which is the dynamic ACE blocker.

Enalapril (Amlodipine) uses

The combination of the drug Enalapril and Amlodipine is used for treating Refractory hypertension .In addition; the combination may also be administered to take care of other ailments not cited in the list above.

Amlodipine+ Enalapril Adverse Reactions / Enalapril (Amlodipine) Side Effects

Angioneurotic oedema, sickness, vomiting, cough, palpitations, fatigue, headache, flushing, chest pain, dizziness, rash; enlargements in BUN, creatinine and serum K levels might take place; neutropaenia. Consult your health care provider in case any problems become chronic and bothersome.

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Special Precautions

  • Lactation.
  • Hepatic and renal disorders , congestive heart problems;
  • Associated potassium supplements and K preserving diuretics, hypovolaemic shock, diuretic treatment;
  •  Sporadic blood count observation to prevent agranulocytosis or neutropaenia.

Other Drug Interactions

Indometacin and additional NSAIDs may dull antihypertensive action. Using it along with diuretics improves antihypertensive outcome.

Possibly acute: Augments lithium intensities and might induce lithium poisoning: Hyperkalaemia with potassium and potassium cautious diuretics. Danger of bone marrow repression owing to enalapril amplified with associated administration of immunosuppressives.

Dosage

Oral

For taking care of Refractory hypertension

For Adult: Each tablet contains 5 mg of amlodipine besylate and 5 mg of enalapril maleate: Initiate with a tablet every day; built up dosage slowly as per response to therapy.

In aged patients: half a tablet to begin with and increase slowly with extreme care. Diuretics ought to be stopped for two to three days prior to initiating the therapy with Enalapril and Amlodipine combination.

Special Populations

Renal dysfunction: half a tablet to begin with and increase slowly with extreme care. Diuretics ought to be stopped for two to three days prior to initiating the therapy with Enalapril and Amlodipine combination.

No precise information available regarding the use of the drug before or after food. Use as instructed by your health care provider or pharmacist.

Enalapril + Amlodipine and Other Contraindications

Avoid if you are allergic to any of the active ingredients.

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