Each Amifru tablet contains:
Frusemide 40 mg
Amiloride 5 mg
Frusemide is an anthranilic acid derivative and very effective in treating several disease states like hepatic disease, renal failure, and congestive heart failure edema. It is also utilized for patients, having impaired renal function as well as thiazide refractory fluid retention. Amiloride is the potassium-retaining agent, having mild natriuretic, diuretic, and antihypertensive properties. The main clinical use of this agent is associated with thiazide or loop diuretic, for preventing hypokalemia as well as lowering the blood pressure. The antihypertensive and diuretic action of the amiloride may considerably potentiate action of the loop diuretic or thiazide.
Frusemide is an effective loop diuretic, having significant antihypertensive and natriuretic properties. However, the therapy with frusemide invariably causes hypokalemia. It necessitates use of amiloride, which is a potassium sparing diuretic. Amiloride is the potassium-retaining agent, having mild natriuretic, diuretic, and antihypertensive properties. Amiloride opposes the hydrogen ion loss and potassium depletion, created by frusemide and minimizes the possibility of developing hypokalemia. The Amiloride also potentiates natriuretic and diuretic activity of the frusemide.
Amifru-40 is used in treating oedematous states, predominantly in the conditions where the potassium ion management is important for instance, Congestive cardiac failure, corticosteroid therapy, nephrosis, and ascites connected with cirrhosis. Amifru-40 is also used in treating mild to moderate essential hypertension.
Dosage & Administration
Amiftu-40 is usually given 1 tablet every day.
Frusemide is very effective diuretic. The common adverse reactions of this drug include electrolyte disturbances, acid base disturbances, and volume depletion that are extensions of the pharmacologic action of reticence H2O and Na re-absorption in ascending the loop of Henle.
Sudden alterations of electrolyte and fluid balance in the patients having cirrhosis can precipitate the hepatic coma. If increasing oliguria and azotemia take place during the treatment of relentless progressive renal disease, then frusemide must be discontinued. Excessive diuresis can result into reduction and dehydration in the volume, having circulatory collapse as well as has option of embolism and vascular thrombosis, predominantly in elderly patients. The elderly patients on the amiloride seem to be prone to hyperkalemia, as glomerular filtration rate reduces with age. Therefore, the renal function lessons are necessary. Acidosis results a change potassium ions from intracellular to extra cellular space with predisposes to hyperkalemia. The periodic serum electrolyte, BUN determinations, and CO2 are advisable in the cases having abnormalities. The same may be corrected or drug should be temporarily withdrawn.
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