Alaspan (Loratadine)

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Alaspan (Loratadine) General information Alaspan (Loratadine) is from the family of antihistamine medicine administered for treating treat allergies, and promoted for its non- sedating actions.

Alaspan (Loratadine)

General information

Alaspan (Loratadine) is from the family of antihistamine medicine administered for treating treat allergies, and promoted for its non- sedating actions.

Pharmacodynamics

Pharmacokinetics

Loratadine (Alaspan) is from the group of non sedating anti-histamine. It functions by carefully binding to secondary histamine H1-receptors on effector cells. 

Absorption

Alaspan (Loratadine) is quickly absorbed from the gastrointestinal tract (oral); highest plasma absorptions after about an hour. Concentration deferred by the existence of food.

Distribution

Found in breast milk, but doesn’t go over the blood-brain barricade. Protein-binding: approximately 98 percent.

 

Metabolism

Broadly hepatic; metabolized to desloratadine (descarboethoxyloratadine).

 

Excretion

Alaspan (Loratadine) generally is discharged through urine and feces (converted as metabolites); abolition half-life roughly 8.4 hours for loratadine and 28 hours approximately for desloratadine.

Alaspan side effects

Fatigue, dizziness, giddiness, dry mouth, nausea, headache and somnolence have been associated to the adverse reactions of Alaspan in the past. Consult a doctor in case any of these side effects occur and create problems.

This may not be the complete list of Alaspan adverse reaction, consult your healthcare provider for detailed information.

Special Precautions

Acute hepatic injury, epilepsy and renal deficiency.

Other Drug Interactions

Plasma absorptions boosted by cimetidine, ketoconazole, erythromycin, nefazodone and probably added inhibitors of CYP3A4.

Dosage

Oral

Hypersensitivity

In case of Adults: Alaspan10 mg once every day.

Child between 2 to 5 yrs: Alaspan 5 mg once every day.

Child between 6 to 12 yrs: Alaspan 10 mg once every day.

In case of patients with renal injury: Amount may require to be decreased to alternate day administration.

In case of patients with Hepatic injury: Amount may require to be decreased to alternate day administration.

Food(before/after)

Alaspan (Loratadine might be used with or without food but advised to use after meal to avoid stomach problems.

List of Contraindications

  • To be used with caution during pregnancy and breast-feeding

Loratadine and Children

Efficacy and Safety not ascertained in kids below 6 yrs of age (tablets) or less than 2 yrs of age (syrup).

Storage

Keep in a cool, dry place at normal room temperature. Avoid exposure to sunlight, heat or moisture. Keep out of the reach of children.

2 comments

SIJI THOMAS
0
Posted on Jun 23, 2012
Roberta Baxter
0
Posted on Jan 23, 2012