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Aerius VS Celestamine: A Comparison Between Two Anti-allergy Medications

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Aerius and Celestamine are popular antihistamines. Aerius is said to be recommendable than Celestamine while the latter is the ultimate relief for allergic conditions. Now, that’s confusing. Here are facts and some clarifications about Aerius and Cele

Allergic conditions have many causes. While some drugs – ingested or injected can lead to hypersensitivity reactions, foods like peanut, eggs, fish can be causative agents too. Through the air we breathe, we can catch pollens, mold spores, dust mites or even insect parts that can trigger our allergic rhinitis or asthma. With our skin, hives, allergic dermatitis or urticaria can be experienced with latex, plants (poison ivy), dyes, chemicals, metal (nickel) or cosmetic contact.

Fortunately, not all individuals are susceptible to allergies. Immunity can be developed on certain allergens and more to this, there are antihistaminic drugs that can control and treat allergic conditions.

Aerius and Celestamine are two popular allergy cures. While, Aerius is said to be recommendable than Celestamine, the latter is the ultimate relief for any allergic conditions. The following are facts about Aerius and Celestamine – which is better between the two.

Aerius facts

Aerius is normally an Rx drug manufactured by Schering plough. It has the generic name desloratadine which is a metabolite or metabolism product of loratadine. As an SGA or the second generation antihistamine, Aerius is known to be non-sedating. Like loratadine, Aerius is also a long-acting antihistamine taken once a day.

Aerius is indicated for symptoms of urticaria as skin itch and hives. It is also used for the relief of cough associated with allergies and symptoms of hay fever as sneezing, water eyes etc.

 

Image by the author

Availability:

Aerius 5mg tablet and 2.5mg/ 5ml syrup (60ml)

Contraindications and special precautions:

Aerius should not be taken by any individual who has hypersensitivity to the drug or with its excipients. It is contraindicated with lactating women. Although, there are no teratogenic effects observed in animal trials with desloratadine, a pregnant woman is not advised to use this drug. Aerius has not established safety in infants below 6 months.

Common side effects:

Expected untoward effects of Aerius are fatigue, dry mouth, headache, diarrhea, fever and insomnia.

Drug interactions:

Aerius as a desloratadine may interact with Amiodarone, an antiarrythmic drug.

Celestamine facts

Celestamine is a combination antiallergy drug of betamethasone and dexchlorpheniramine maleate. It is a prescription type, manufactured by Essex. Celestamine is categorized under the Antihistamines and Antiallergics; however it is also classified under the corticosteroids. While, dexchlorpheniramine maleate provides the antihistaminic or anti-allergy action, betamethasone acts as the corticosteroid support.

Celestamine is used for the treatment of difficult cases of respiratory, skin and eye allergies and other disorders that needs corticosteroid therapy. Its dosing depends on the age and the severity of the condition.

 

Image by the author

Availability:

Celestamine (Betamethasone 250 mcg, dexchlorpheniramine maleate 2 mg) tablet

Celestamine (Betamethasone 250 mcg, dexchlorpheniramine maleate 2 mg) per 5ml 60 and 120 bottle

Contraindications and special precautions:

  • With bethamethasone

Because Celestamine has betamethasone as an active constituent, it is contraindicated with infants and with people who have fungal infections. It is not to be used by an individual has a known hypersensitivity to it. Celestamine Syrup contains FD and C yellow #5 which may cause allergic reactions including bronchial asthma in susceptible people.

Corticosteroids like betamethasone may suppress the immune system resulting to lack of antibody response. If the patient is under any immunization procedure, dangers of neurological complications can be possible.

Celestamine is used in precaution with patients having disorders like hypothyroidism, cirrhosis, renal insufficiency, hypertension, osteoporosis, myasthenia gravis, active tuberculosis and in GIT conditions as ulcerative colitis, diverticulitis, peptic ulcer etc.

Prolonged corticosteroid therapy may retard growth in children.

Corticosteroids may mask signs of infection.

It can impair fertility in men by altering the motility and number of sperms.

Celestamine use in lactating and pregnant women is contraindicated. Children born to mothers who have received corticosteroids during pregnancy is observed for signs of hypoadrenalism.

  •  With dexchlorpheniramine

Dexchlorpheniramine maleate is an FGA or first generation antihistamine that can cause drowsiness. With this, Celestamine use should be warned in patients who need to engage in activities requiring mental alertness as driving or operating machines. Dexchlorpheniramine is also to be used in caution with individuals having narrow angle glaucoma, stenosing peptic ulcer, pyloroduodenal obstruction, prostatic hypertrophy or bladder neck obstruction, cardiovascular disease including hypertension, in those with increased intraocular pressure and hyperthyroidism.

Common side effects:

  • With betamethasone

Adverse reactions usually involve the musculoskeletal as muscle weakness and osteoporosis; gastrointestinal as peptic ulcer, ulcerative esophagitis, pancreatitis etc; dermatologic as allergic dermatitis and utricaria; neurologic as convulsion, vertigo and headache; endocrine as menstrual irregularities and cushingoid state; ophthalmic as cataracts and glaucoma; psychiatric as euphoria, mood swings and insomnia.

  •  With dexchlorpheniramine

Sedation

 Drug interactions:

  • With bethamethasone

Phenobarbital, phenytoin, rifampicin, ephedrine can increase the metabolism of betamethasone thus reducing the effect of Celestamine.

 Betamethasone with alcohol can increase occurrence of gastrointestinal ulceration.

 Betamethasone with digitalis (Digoxin) can enhance the possibility of arrhythmias or digitalis toxicity.

More to this, as a corticosteroid, betamethasone can lessen the effect of diuretics, aspirin, anti-diabetic agents and the anti-cholinesterases (e.g. physostigmine).

  •  With dexchlorphenamine

Monoamine oxidase (MAO) inhibitors can prolong and exaggerate the effects of dexchlorphenamine. Alcohol, tricyclic antidepressants, barbiturates or other central nervous system depressants can also increase the sedative effect of this antihistamine. Finally, oral anticoagulants effect may be decreased by dexchlorphenamine.

Aerius and Celestamine comparison

Which is better?

Celestamine is better than Aerius in terms of immediate effect because it has a corticosteroid as an active constituent. In serious allergy symptoms, corticosteroids are normally indicated as an option if antihistamines fail to work. However, Celestamine use is limited because of its numerous untoward side effects.

Which is recommendable?

Aerius is recommendable because it has the least side effects and it does not cause sedation. SGA types like Aerius is safer to be used in treatment of seasonal allergies unlike Celestamine.

Important:

This article is solely for information. A physician’s diagnosis is dependent on his patient’s case and background history.

© Phoenix Montoya @ July 4, 2011

References:

http://www.medicinenet.com/allergy/page8.htm

http://www.mims.com/Philippines/drug/info/Aerius/?q=aerius&type=brief

http://www.mims.com/Philippines/drug/info/Celestamine/?q=celestamine&type=brief

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Phoenix Montoya

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